Expression of BCL-2 and KI-67 in Cyclical Endometrium and in Endometrial Hyperplasia
P. Shalini
Department of Pathology, Sree Balaji Medical College & Hospital, Chennai – 600044, India.
Natrajan Suresh
Department of Pathology, Sree Balaji Medical College & Hospital, Chennai – 600044, India.
S. Mary Lilly *
Department of Pathology, Sree Balaji Medical College & Hospital, Chennai – 600044, India.
*Author to whom correspondence should be addressed.
Abstract
The Present study attempts to determine the relationship between proliferation and the inhibition of apoptosis in normal endometrium and hyperplasia, using monoclonal antibodies against the proliferation marker, Ki-67 and the anti-apoptotic protein, Bcl-2 and to determine the expression of B-cell lymphoma 2 (Bcl – 2) and Ki – 67 in cyclical endometrium in proliferative and secretory phase. The Present study includes the expression of Bcl – 2 and Ki – 67 in endometrial hyperplasia.
Keywords: Endometrium, apoptosis, Bcl – 2, Ki-67, hematoxylin, biopsy and xylene