High Sensitive C- Reactive Protein in Patients with Angiographically Proved Coronary Artery Disease
Anil Bhattad
Medicine Department, Krishna Institute of Medical Sciences, Karad, India.
A. T. Pardesi *
Medicine Department, Krishna Institute of Medical Sciences, Karad, India.
Nitin Jadhav
Medicine Department, Krishna Institute of Medical Sciences, Karad, India.
Vaibhav Agarwal
Medicine Department, Krishna Institute of Medical Sciences, Karad, India.
Jabbar Desai
Medicine Department, Krishna Institute of Medical Sciences, Karad, India.
R. J. Kapale
Medicine Department, Krishna Institute of Medical Sciences, Karad, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Atherosclerosis is associated with increased inflammatory activity and risk of vascular disease. The hypothesis is that, the hs-CRP testing might have prognostic usefulness for patients with CAD. Considering a major role of hs-CRP in atherothrombosis, its measurements can provide a novel method to detect individuals at high risk of rupture of plaque.
Aim of the Work: This study was performed to find out the relation of high sensitive CRP (hs-CRP) with angiographically proved coronary artery disease (CAD) and its severity.
Methodology: Total 125 patients underwent CAG in present study, of them 36% were females and 64% were males, predominated by male sex (‘p’ <0.001.
Results: The mean for hs-CRP levels was 1.67(±0.85) mg/L and significantly high in patient with CAD. Strong correlation was formed between age ≥ 45 years and hs-CRP 1-3 mg/ L in present cohort of CAD. About one third of population with CAD had dyslipidemia of them majority (2/3rd) had hs-CRP 1-3 mg/L. Two-third of patients with CAD with tobacco consumption in any form had hs-CRP 1-3 mg/L and was significant than < 1 mg/L and >3 mg/L hs-CRP level. The hs-CRP level associated favorably with the frequency and extent of the CAD in present study (r=0.664).
Conclusion: High sensitive CRP offers better risk stratification, predictive and prognostic value, in patients with CAD. Further studies and interventions are mandatory to identify the independent role of hs-CRP as a CAD risk factor and its cost effectiveness in a population of a developing country like India.
Keywords: Angiographically, C - reactive protein, hs-CRP, coronary artery disease.