Anti-infective Therapy Principles in Diseases Caused by Bacterial Biological Agents
Viorel Ordeanu
Military Medical Research Center, Bucharest, Romania and Titu Maiorescu University, Bucharest, Romania.
Marius Necsulescu
Military Medical Research Center, Bucharest, Romania.
Lucia E. Ionescu
Military Medical Research Center, Bucharest, Romania.
Diana M. Popescu *
Military Medical Research Center, Bucharest, Romania.
Simona N. Bicheru
Military Medical Research Center, Bucharest, Romania.
Gabriela V. Dumitrescu
Military Medical Research Center, Bucharest, Romania.
Radu G. Hertzog
Military Medical Research Center, Bucharest, Romania.
*Author to whom correspondence should be addressed.
Abstract
The international situation requires the strengthening of national security measures, including CBRN field and public health. Infectious diseases, and especially infectious-contagious diseases, represent the main threat to public health and have the highest prevalence of morbidity and mortality. These are classified by the World Health Organization in first group of human diseases. The situation may be even worse concerning biological warfare (BWA) and bioterrorism agents.
The great successes of modern medicine, looking from a holistic perspective at the species level, are based on vaccination and antibiotherapy. But, lately, some serious problems arose. The antibiotics (AB), antibacterial miracle drugs, are losing their effectiveness due to the increase in antibiotic resistance (AMR) of bacteria, a phenomenon that will worsen in the future; so, we are already discussing the end of the antibiotic era and the need for new anti-infective therapy concepts. And, as if this medical catastrophe was not enough, the "anti-vaccine" movement that undermines the specific prophylaxis of infectious diseases also appeared. Moreover, in this dangerous context to public health, the threats of biological warfare and bioterrorism are outlined.
Keywords: Biological agents, biological weapons, infectious diseases, anti-infective therapy, anti-infective medical protection.