Anti-inflammatory and Antioxidant Potential of Hyaluronic Acid Mediated Zinc Nanoparticles
N. Akash
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-77, Tamil Nadu, India.
Lakshminarayanan Arivarasu *
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai-77, Tamil Nadu, India.
S. Rajeshkumar
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai-77, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: The aim of the study is to interpret the hyaluronic acid mediated with zinc oxide nanoparticle and its anti-inflammatory and antioxidant activity.
Introduction: Hyaluronic acid has a role as ‘physiological selector’ for spermatozoa prior to intracy to plasmic sperm injection (icsi). They are mostly seen in the synovial joints and act as a shock absorber. The objective of this study is to analyse the results achievable by the introduction of a routine HA. Hyaluronic acid is an immune neutral polysaccharide that is ubiquitous in the human body, and it is crucial for many cellular and tissue functions. Nanoparticles are the compounds which respond to the applied magnetic fields, magnetic separation labelled cells, therapeutic drug, gene and radionuclide delivery and other biological entities.
Materials and Methods: Hyaluronic acid mediated with zno nanoparticles were evaluated for its anti inflammatory activity and antioxidant potential using photometry analysis.
Results and Discussion: Zinc nanoparticles shows a higher efficiency of antibacterial activity, but sublethal concentration causes adverse effects and results in increased biofilm formation of V. cholerae Hyaluronic acid mediated zinc oxide nanoparticle show good result in anti inflammatory activity as well as in antioxidant activity. The biosynthesis of the nanoparticle was done by addition of hyaluronic acid with zinc nanoparticles in a scarese amount. This was kept in the orbital shaker, hence they take a long time for the synthesis. The colour change was observed, hence the synthesized nanoparticles proceeded with the anti-inflammatory and antioxidant tests.
Keywords: Anti inflammatory, hyaluronic acid, anti-oxidant, anti-microbial