Nigella sativa Derived Phytochemicals against Cough
Diptiprajnya Sahoo
Centurion University of Technology and Management, Odisha, India.
Minati Nayak
Centurion University of Technology and Management, Odisha, India.
Sidhartha Ray
Centurion University of Technology and Management, Odisha, India.
Mukundjee Pandey *
Centurion University of Technology and Management, Odisha, India.
Kalpita Bhatta
Centurion University of Technology and Management, Odisha, India.
Sushree Susmita Palei
Centurion University of Technology and Management, Odisha, India.
Debasmita Rautaray
Centurion University of Technology and Management, Odisha, India.
*Author to whom correspondence should be addressed.
Abstract
Nigella sativa plant extract is traditionally used to cure cough. It is caused by Bordetella pertussis. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that p-cymene can effectively deactivate the adenylate cyclase thereby interrupting the life cycle of the organism.
Keywords: Phytochemicals, Nigella sativa, Bordetella pertussis, cough.