Impact of Foeniculum vulgare Fortified Diet on Coagulation Profile and Some Biochemical Parameters
Afshan Abbas *
Sir Syed College of Medical Sciences for Girls, Rojhan Street, Block 5, Clifton, Karachi, Pakistan.
Rahila Ikram
University of Karachi, Gulshan-e-Iqbal, Karachi, Pakistan.
Faiza Hasan
Fatima Jinnah Dental College, 100 Foot Road, Azam Town Adjacent to D.H.A. Phase 1 Defence Housing Authority, Karachi, Pakistan.
Qurrat Ul Ain Bukhari
Sir Syed College of Medical Sciences for Girls, Rojhan Street, Block 5, Clifton, Karachi, Pakistan.
Sana Sarfaraz
University of Karachi, Gulshan-e-Iqbal, Karachi, Pakistan.
Abeer Adil
Jinnah University for Women, Street 1, 5-C Nazimabad, Karachi, Pakistan.
*Author to whom correspondence should be addressed.
Abstract
Aims: Coagulation profile shows the clotting ability of blood. Biochemical tests indicate health status of vital organs such as liver, heart and kidneys. Herbal products are being assessed for their role in affecting these parameters. We evaluated role of Foeniculum vulgare incorporated diet on coagulation profile and some important biochemical parameters.
Study Design: Laboratory centred randomized controlled trial.
Place and Duration of Study: Pharmacology Department of University of Karachi, Karachi between June 2018 and September 2018.
Methodology: After selecting 30 healthy rabbits of either sex, we placed them in three groups; Control, 2% Foeniculum vulgare and 4% Foeniculum vulgare group. Control group was given standard diet whereas; 2% and 4% Foeniculum vulgare groups were maintained on standard diet containing 2% and 4% Foeniculum vulgare crushed seeds. Coagulation profile and some biochemical parameters were done after interval of a month, for two months.
Results: Platelet count and fibrinogen increased while activated partial thromboplastin time (APTT) levels decreased in both the study groups animals as compared to control, while blood urea nitrogen (BUN), creatinine phosphokinase (CPK) and lactate dehydrogenase (LDH) elevation was noted both Foeniculum vulgare groups but within normal range.
Conclusion: Foeniculum vulgare may have some role in affecting coagulation and biochemical profile These parameters, however, need clinical trial to validate reliability.
Keywords: Activated partial thromboplastin time, blood urea nitrogen, creatinine phosphokinase, Foeniculum vulgare, lactate dehydrogenase.