Comparative Evaluation of the Adverse Effects of Vaccination against COVID-19 Infection among the Population in Central India

Background: India's Covaxin and Covishield has associate effectiveness rate of 81% preliminary info. Both vaccines have shown excellent safety and efficacy. Objectives: To seek the information about vaccination side effect and Covid-19 infection after getting vaccination. Methodology: We are examining the self-reported vaccination side effect on local and systemic side-effects within 8 to 15 days and covid 19 infections who received one or two doses of the covisheld or a covaxin. Expected Results: The expected results of this study will determine the vaccination adverseeffects of covaxin and covishield with its probability of Covid-19 infection among the dental professionals after getting vaccination in state of Maharashtra. Conclusion: An observational based study in which we have to identify vaccination side effects and infection after administration of both Coronavirus vaccines which are use in India. Both the vaccines area associate effectiveness rate of 81%. Study Protocol Bais et al.; JPRI, 33(60B): 2688-2691, 2021; Article no.JPRI.80023 2689


INTRODUCTION
The India's drug regulator gave disaster approval to corornavirus 2019 vaccines for using against corona virus disease even when 3 rd phase clinical study for Covaxin is going on. On 3 January, the Indian general drugs controllers are approved the booster as a "heavy safeguard" in opposition the spread of the high contagious variant which is found in the Britain. India is the 2 nd highest infected country in the world with more than 150,000 deaths due to coronavirus 2019 till December.

Rationale
This study will help to observe numbers of healthcare professionals are affected with vaccination side effect and covid infection after getting vaccination. We aimed to study safety and prospect of vaccination in Maharashtra.

Objectives
 To evaluate the comparisons of adverse effects of vaccination against COVID 19 i. e Covishield and Covaxin.  To evaluate the co-relation of adverse effects of vaccination with age groups, gender, BMI, co-morbidities, Frequency of dose and covid infection post vaccination.

Selection Criteria
Participants with Age group > 18 to 45 years, 45 years above, >45 years with co morbidities.

Measurement
It is an online cross-sectional Survey conducted in Sharad pawar dental college and hospital among central India. The questions will be distributed to all dental healthcare professionals. Age group is distributed as > 18 to 45 years, 45 years above, >45 years with co morbidities. A questionnaire form is designed to record all relevant information. The questionnaire consisted a total 25 items to observe the adverse effects of vaccination against Covid-19 in India i.e. Covaxin and Covishield and recording the demographic details with Covid-19 infection post vaccination among the dental health professionals in state of Maharashtra.
Quantitative variables: All the demographic details and the questions in relation to the questionnaire will be recorded with the help of electronic forms and record in the excel sheet. Statistical methods: Statistical software of SPSS version 22 has been used for the analysis. Descriptive analysis and frequency distribution test will be used to assess the responses of the participants towards the questionnaire.
Pearson co-relation and logistic regression analysis will be used for estimating the corelation of adverse effects of vaccination with age groups, gender, BMI, co-morbidities, Frequency of dose and covid infection post vaccination.

EXPECTED OUTCOMES/RESULTS
The expected results of this study will determine the vaccination adverse-effects of covaxin and covishield with its probability of coronavirus 2019 infection among dental professionals after getting vaccination in state of Maharashtra.

DISCUSSION
A prospective study was conducted in UK: Vaccine side effect and SARS-CoV2 infection after vaccination in users of covid symptoms study app. They aimed to investigate the safety and effectiveness of these vaccines in UK. They examined the quality and prospect of selfreported local and systemic side effects between 8 days of vaccination every single person is using covid symptoms study app. They also analyze the infection rates in subsets of vaccinated every single subsequent tested for coronavirus with PCR or lateral flow test with infection rates in unvaccinated controls. In phase 3 trials they conclude that local and systemic side effects after vaccination occur at lower frequency. After 12 days both the vaccines decrease the risk of coronavirus infection [4].
A randomized control study was conducted in United States: adverse effect with coronavirus 2019 mRNA 1273 vaccine. The aim of study was to investigate the side effect of mRNA 1273 vaccine on healthcare workers. Through an independent online questioner serve they conclude that many of the symptoms reported are not hazardous. Of these, 58.8% where able to continue routeing activity, 25% had temporary trouble to perform daily activities, 27.78% required short time off from work. 3.94% required outpatient provider, 0.23% required emergency help. Despite the broad arrangement of selfreported symptoms are shown to be a large number of receiving for this vaccine [

CONCLUSION
A community-based study in which we have to investigate assessment of adverse effects of Covid 19 Vaccination among dental health professionals in state of Maharashtra. Both the vaccines are associate effectiveness rate of 81%.